Schematic representation of activated and inhibited Wnt/?-catenin pathway. “WNT ON state?? On ligation of Wnts for their receptors composed of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3?. Subsequently, stabilized ?-catenin translocates to the nucleus and binds to TCF/LEF transcriptio